Portuguese international ended the match with a goal and three assists.
Away from Luciano Spalletti at the start of the season, João Mário was, for the first time in a row, for the second time in a row for Inter Milan, and he corresponded in the best way.
In front of Genoa, the Portuguese Pedro Pereira (owner), Miguel Veloso (substitute used) and Iuri Medeiros (did not leave the bench), the former Sporting left his mark in the 14 minutes when he watched Roberto Gagliardini for the first goal pm.
Only two minutes later, the Portuguese returned to make their own, this time when making the pass from which was born the goal of Matteo Politano. Already in the second half, Gagliardini struck out and, over the final whistle, João Mário, with a nice shot from outside the area, made the taste to the foot.
But the midfielder was not fully convinced and, in time for compensation, crossed into the header of Radja Nainggolan, who closed the score at 5-0.
With this triumph, Inter Milan will add 25 points and return to catch Naples in second place in Serie A, three points behind Juventus, Cristiano Ronaldo and João Cancelo, which has, however, one less game.
Genoa, who do not know what it is to win since the end of September, maintains with 14 points and risks losing the 11th position of the Italian championship.